Acute adjunctive therapy for bipolar disorder

Acute adjunctive therapy for bipolar disorder

• A. Short-term management of aggression and/or psychosis-related inappropriate behaviors
• B. Depressive episode treatment in bipolar disorder
• C. Lurasidone, quetiapine, fluoxetine/olanzapine combo
• D. Psychosis (olanzapine, quetiapine), inappropriate sexual behavior, visual hallucinations refractory to donepezil

Answer: (C)

Acute adjunctive therapy in bipolar disorder means adding specific medications to a mood stabilizer to rapidly control symptoms during an active episode, especially when depressive symptoms or psychotic features are present. Lurasidone and quetiapine are antipsychotics with strong evidence for efficacy in bipolar depression and are commonly used as add-ons to speed relief. The fluoxetine/olanzapine combination is an approved antidepressant-augmentation regimen for bipolar depression, useful for improving depressive symptoms when a mood stabilizer alone isn’t enough. Together, these options reflect accepted strategies to address acute bipolar symptoms beyond what a mood stabilizer can achieve. Other choices describe management targets (like aggression or psychosis) or contexts not specifically about acute adjunctive treatment for bipolar depression, so they’re not as fitting.

Acute adjunctive therapy in bipolar disorder means adding specific medications to a mood stabilizer to rapidly control symptoms during an active episode, especially when depressive symptoms or psychotic features are present. Lurasidone and quetiapine are antipsychotics with strong evidence for efficacy in bipolar depression and are commonly used as add-ons to speed relief. The fluoxetine/olanzapine combination is an approved antidepressant-augmentation regimen for bipolar depression, useful for improving depressive symptoms when a mood stabilizer alone isn’t enough. Together, these options reflect accepted strategies to address acute bipolar symptoms beyond what a mood stabilizer can achieve. Other choices describe management targets (like aggression or psychosis) or contexts not specifically about acute adjunctive treatment for bipolar depression, so they’re not as fitting.