Clozapine

Clozapine

• A. Postpartum psychosis treatment
• B. Bipolar disorder manic episode treatment
• C. Tardive dyskinesia treatment
• D. Lewy Body dementia treatment

Answer: (C)

Clozapine’s distinctive receptor profile gives it a much lower risk of extrapyramidal symptoms than other antipsychotics, and it can even improve tardive dyskinesia in some patients. Because tardive dyskinesia results from long-term dopamine blockade, a drug that avoids strong nigrostriatal D2 antagonism can reduce or reverse TD symptoms. Clozapine achieves this with weak D2 blockade and prominent 5-HT2A antagonism, making it a useful option when TD is a concern or when treating treatment-resistant schizophrenia. In contrast, postpartum psychosis, manic episodes in bipolar disorder, and Lewy body dementia are not situations where clozapine is typically the treatment of choice due to standard treatment approaches or sensitivity to antipsychotics in Lewy body dementia.

Clozapine’s distinctive receptor profile gives it a much lower risk of extrapyramidal symptoms than other antipsychotics, and it can even improve tardive dyskinesia in some patients. Because tardive dyskinesia results from long-term dopamine blockade, a drug that avoids strong nigrostriatal D2 antagonism can reduce or reverse TD symptoms. Clozapine achieves this with weak D2 blockade and prominent 5-HT2A antagonism, making it a useful option when TD is a concern or when treating treatment-resistant schizophrenia. In contrast, postpartum psychosis, manic episodes in bipolar disorder, and Lewy body dementia are not situations where clozapine is typically the treatment of choice due to standard treatment approaches or sensitivity to antipsychotics in Lewy body dementia.