Transient neutropenia has been reported with which antipsychotic?

Transient neutropenia has been reported with which antipsychotic?

• A. Haloperidol
• B. Clozapine
• C. Risperidone
• D. Ziprasidone

Answer: (B)

Clozapine is the antipsychotic most notably linked to hematologic toxicity, including neutropenia and, more seriously, agranulocytosis. Because of this risk, patients on clozapine require regular blood monitoring to catch drops in neutrophils early. Transient neutropenia can occur with clozapine and may resolve with continued therapy or dose adjustment, but it is a well-recognized safety signal for this medication. Other antipsychotics like haloperidol, risperidone, and ziprasidone do not carry this same, prominent risk and are not associated with the need for routine neutrophil monitoring.

Clozapine is the antipsychotic most notably linked to hematologic toxicity, including neutropenia and, more seriously, agranulocytosis. Because of this risk, patients on clozapine require regular blood monitoring to catch drops in neutrophils early. Transient neutropenia can occur with clozapine and may resolve with continued therapy or dose adjustment, but it is a well-recognized safety signal for this medication. Other antipsychotics like haloperidol, risperidone, and ziprasidone do not carry this same, prominent risk and are not associated with the need for routine neutrophil monitoring.