What is the D2 receptor occupancy range reported?

What is the D2 receptor occupancy range reported?

• A. 85-94%
• B. 60-70%
• C. 70-80%
• D. 90-100%

Answer: (A)

D2 receptor occupancy tells us how much of the dopamine D2 receptors are blocked by an antipsychotic at a given dose. Clinically effective antipsychotic treatment tends to push receptor blockade into the high-80s to mid-90s percent range, because you need substantial blockade to reduce psychotic symptoms while avoiding excessive blockade that raises extrapyramidal risk. The range 85-94% is repeatedly reported in PET studies as the occupancy seen with standard, therapeutically dosed antipsychotics. This reflects the balance clinicians observe: strong enough receptor blockade to control symptoms, yet not so high as to guarantee severe motor side effects. Some drugs at certain doses can approach the lower 80s or even the mid-90s, but 85-94% captures the typical reported window across diverse agents and protocols.

D2 receptor occupancy tells us how much of the dopamine D2 receptors are blocked by an antipsychotic at a given dose. Clinically effective antipsychotic treatment tends to push receptor blockade into the high-80s to mid-90s percent range, because you need substantial blockade to reduce psychotic symptoms while avoiding excessive blockade that raises extrapyramidal risk.

The range 85-94% is repeatedly reported in PET studies as the occupancy seen with standard, therapeutically dosed antipsychotics. This reflects the balance clinicians observe: strong enough receptor blockade to control symptoms, yet not so high as to guarantee severe motor side effects. Some drugs at certain doses can approach the lower 80s or even the mid-90s, but 85-94% captures the typical reported window across diverse agents and protocols.