Which antipsychotic combination has the lowest metabolic risk?

Which antipsychotic combination has the lowest metabolic risk?

• A. Clozapine and Olanzapine
• B. Quetiapine and Risperidone
• C. Ziprasidone and Aripiprazole
• D. Lurasidone and Haloperidol

Answer: (C)

Metabolic risk with antipsychotics relates to how much each drug tends to promote weight gain, insulin resistance, and lipid abnormalities. Some agents, like clozapine and olanzapine, carry high metabolic risk, while others have relatively low or neutral effects on metabolic parameters. When aiming for the lowest overall metabolic burden, choosing two medications with favorable metabolic profiles makes sense. Ziprasidone and aripiprazole both tend to cause little weight gain and have minimal impact on glucose and lipid levels, so using them together yields the smallest chance of metabolic disturbance compared with the other pairings, which involve drugs with higher metabolic risk.

Metabolic risk with antipsychotics relates to how much each drug tends to promote weight gain, insulin resistance, and lipid abnormalities. Some agents, like clozapine and olanzapine, carry high metabolic risk, while others have relatively low or neutral effects on metabolic parameters. When aiming for the lowest overall metabolic burden, choosing two medications with favorable metabolic profiles makes sense. Ziprasidone and aripiprazole both tend to cause little weight gain and have minimal impact on glucose and lipid levels, so using them together yields the smallest chance of metabolic disturbance compared with the other pairings, which involve drugs with higher metabolic risk.