Which drug has adverse effects including somnolence and QT prolongation?

Which drug has adverse effects including somnolence and QT prolongation?

• A. Benadryl
• B. Valbenazine
• C. Cogentin
• D. Haloperidol

Answer: (B)

Somnolence plus QT prolongation point to a drug with both CNS depressant effects and a known cardiac safety risk. Valbenazine, a VMAT2 inhibitor used for tardive dyskinesia, is specifically associated with these adverse effects. The sedative effect explains the somnolence, while the QT prolongation flag signals potential cardiac risk that needs monitoring. The other meds listed have different primary safety profiles (for example, anticholinergic effects or extrapyramidal symptoms are more central to their adverse effect patterns), so they don’t uniquely combine somnolence and QT prolongation like valbenazine does.

Somnolence plus QT prolongation point to a drug with both CNS depressant effects and a known cardiac safety risk. Valbenazine, a VMAT2 inhibitor used for tardive dyskinesia, is specifically associated with these adverse effects. The sedative effect explains the somnolence, while the QT prolongation flag signals potential cardiac risk that needs monitoring. The other meds listed have different primary safety profiles (for example, anticholinergic effects or extrapyramidal symptoms are more central to their adverse effect patterns), so they don’t uniquely combine somnolence and QT prolongation like valbenazine does.