Which items are included in the metabolizing enzymes/Transporters group?

Which items are included in the metabolizing enzymes/Transporters group?

• A. CYP1A2 and CYP3A4
• B. CYP1A2 and P-gp
• C. UGT1A4 and P-gp
• D. CYP2D6 and UGT1A4

Answer: (C)

Metabolizing enzymes and transporters represent two sides of how drugs are handled by the body: enzymes chemically modify drugs to aid elimination, and transporters move drugs across cell membranes to influence absorption, distribution, and excretion. UGT1A4 is a metabolizing enzyme that performs glucuronidation, tagging drugs for easier excretion by making them more water-soluble. P-glycoprotein (P-gp) is a key transporter that pumps many drugs out of cells, affecting how much drug reaches its target sites, including the brain. Choosing UGT1A4 together with P-gp best illustrates both components of this group in one item: one enzyme involved in metabolism and one transporter involved in movement across membranes. The other options either show two enzymes without a transporter or mix a transporter with an enzyme that doesn’t highlight the combined enzymatic/transport roles as clearly.

Metabolizing enzymes and transporters represent two sides of how drugs are handled by the body: enzymes chemically modify drugs to aid elimination, and transporters move drugs across cell membranes to influence absorption, distribution, and excretion. UGT1A4 is a metabolizing enzyme that performs glucuronidation, tagging drugs for easier excretion by making them more water-soluble. P-glycoprotein (P-gp) is a key transporter that pumps many drugs out of cells, affecting how much drug reaches its target sites, including the brain.

Choosing UGT1A4 together with P-gp best illustrates both components of this group in one item: one enzyme involved in metabolism and one transporter involved in movement across membranes. The other options either show two enzymes without a transporter or mix a transporter with an enzyme that doesn’t highlight the combined enzymatic/transport roles as clearly.