Which medication is used for drug-induced psychosis?

Which medication is used for drug-induced psychosis?

• A. Clozapine
• B. Olanzapine
• C. Paliperidone
• D. Risperidone

Answer: (D)

Drug-induced psychosis is typically treated by using an antipsychotic to rapidly control acute psychotic symptoms and agitation, while considering tolerability and the ability to use the drug in a patient who may be using substances. Risperidone, a second-generation antipsychotic, blocks dopamine D2 receptors to reduce hallucinations and delusions and also antagonizes serotonin 5-HT2A receptors, which can improve mood and reduce some motor side effects compared with older antipsychotics. This pharmacologic profile helps calm agitation quickly and address positive symptoms common in substance-induced psychosis, making it a practical choice in acute settings. It can be given orally and, if adherence is a concern, as a long-acting injectable, which is advantageous in patients with ongoing substance use. Other options have different risk profiles or indications (for example, clozapine is typically for treatment-resistant cases; olanzapine carries metabolic risks; paliperidone is a close relative with similar effects but not inherently superior for acute drug-induced psychosis), so risperidone often emerges as a favorable choice in this scenario.

Drug-induced psychosis is typically treated by using an antipsychotic to rapidly control acute psychotic symptoms and agitation, while considering tolerability and the ability to use the drug in a patient who may be using substances. Risperidone, a second-generation antipsychotic, blocks dopamine D2 receptors to reduce hallucinations and delusions and also antagonizes serotonin 5-HT2A receptors, which can improve mood and reduce some motor side effects compared with older antipsychotics. This pharmacologic profile helps calm agitation quickly and address positive symptoms common in substance-induced psychosis, making it a practical choice in acute settings. It can be given orally and, if adherence is a concern, as a long-acting injectable, which is advantageous in patients with ongoing substance use. Other options have different risk profiles or indications (for example, clozapine is typically for treatment-resistant cases; olanzapine carries metabolic risks; paliperidone is a close relative with similar effects but not inherently superior for acute drug-induced psychosis), so risperidone often emerges as a favorable choice in this scenario.