Which of the following is NOT listed as an anticholinergic medication?

Which of the following is NOT listed as an anticholinergic medication?

• A. Amitriptyline
• B. Clomipramine
• C. Desipramine
• D. Sertraline

Answer: (D)

Anticholinergic effects come from medications that block muscarinic acetylcholine receptors, leading to dry mouth, constipation, urinary retention, blurred vision, and cognitive slowing, especially in older adults. Among the drugs listed, amitriptyline and clomipramine are classic tricyclic antidepressants with strong anticholinergic (antimuscarinic) activity. Desipramine is a tricyclic antidepressant with relatively lower anticholinergic effects, though not completely free of them. Sertraline, on the other hand, is an SSRI and typically has minimal anticholinergic activity, so it does not carry the same anticholinergic burden as the TCAs. Thus, sertraline is not listed as an anticholinergic medication.

Anticholinergic effects come from medications that block muscarinic acetylcholine receptors, leading to dry mouth, constipation, urinary retention, blurred vision, and cognitive slowing, especially in older adults. Among the drugs listed, amitriptyline and clomipramine are classic tricyclic antidepressants with strong anticholinergic (antimuscarinic) activity. Desipramine is a tricyclic antidepressant with relatively lower anticholinergic effects, though not completely free of them. Sertraline, on the other hand, is an SSRI and typically has minimal anticholinergic activity, so it does not carry the same anticholinergic burden as the TCAs. Thus, sertraline is not listed as an anticholinergic medication.